It’s a top of the table Scudetto showdown, as Inter look to Lautaro Martinez, Marcus Thuram and Hakan Calhanoglu against Napoli’s Romelu Lukaku, Khvicha Kvaratskhelia and Scott McTominay.
It kicks off at the Stadio Giuseppe Meazza in San Siro at 19.45 GMT.
There was only one point separating the two teams going into this weekend, as the leaders were beaten 3-0 at home by Atalanta to blow the race wide open.
The Nerazzurri are coming off a midweek Champions League victory over Arsenal, despite resting several of their top stars.
They all return here, including Federico Dimarco, Alessandro Bastoni, Nicolò Barella, Henrikh Mkhitaryan and Thuram.
Even Francesco Acerbi is available again for the first time since October 20, so the only injury absentee is Carlos Augusto.
This will always be a special match for former Inter coach Conte and his star striker Lukaku, although the latter left in rather more bitter circumstances and will be loudly jeered.
Stanislav Lobotka is back on the bench for the first time in a month, but Billy Gilmour again takes the midfield reins.
McTominay, Matteo Politano and Kvaratskhelia fan out in support of Lukaku.
Here too, the only player out of action is Michael Folorunsho.
Inter vs. Napoli line-ups
Inter: Sommer; Pavard, Acerbi, Bastoni; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; M Thuram, Lautaro Martinez
Napoli: Meret; Di Lorenzo, Rrahmani, Buongiorno, Olivera; Anguissa, Gilmour, McTominay; Politano, Lukaku Kvaratskhelia
Player statistic
23' | Scott McTominay (Assist: Amir Rrahmani) | |||
Hakan Calhanoglu (Assist: Alessandro Bastoni) |
43' |
Hakan Calhanoglu | 74' | |||
Denzel Dumfries | 80' |